PRECLINICAL- 4-quinolone prodrugs, pP4Q-414 , potential treatment of multi-drug resistant Plasmodium falciparum malaria

New Drug Approvals

Medicines for Malaria Venture is investigating 4-quinolone prodrugs including pP4Q-414 (structure shown) and pP4Q-435, for the potential treatment of multi-drug resistant Plasmodium falciparum malaria.

In April 2013, data were presented at the 104th AACR Meeting in Washington DC. Of the compounds screened, pP4Q-414 and pP4Q-435 prodrug of P4Q-146 and P4Q-158 respectively, showed potent activity against P falciparum. In vivo, of the five mice evaluable, one mouse was cured with pP4Q-414 (at po 10 mg/kg) treatment and two of the five mice were cured with pP4Q-435 (at po 50 mg/kg) treatment

View original post

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s