Analysis Of Vical’s Allovectin-7: Best Results Ever In A Melanoma Phase 3 Trial

New Drug Approvals

check this video

…………….

immunotherapy - cancer

Vical’s (VICL) Allovectin-7 is a pure immune therapy.(1) Which means it does not directly kill cancer cells, but activates the immune system to do so. Vical will soon announce A-7 phase 3 results in Melanoma, but the mechanism of action is not specific to Melanoma, and can be used in any solid tumor cancer.(2) For this reason, I expect that Allovectin-7 will become one of the best selling cancer drugs of all time.

http://seekingalpha.com/article/1584402-analysis-of-vicals-allovectin-7-best-results-ever-in-a-melanoma-phase-3-trial?source=google_news

Allovectin-7 is a substance that is being studied as a gene therapy agent in the treatment of cancer, such as malignant melanoma. It is a plasmid/lipid complex containing the DNA sequences encoding HLA-B7 and ß2 microglobulin – two components of major histocompatibility complex (MHC, class I). It increases the ability of the immune system to recognize cancer cells and kill them.

In 1999, FDA granted Allovectin-7 orphan…

View original post 186 more words

Gene Therapy for Melanoma: Progress and Perspectives

New Drug Approvals

media/image1.jpeg

FIGURE 1.

http://www.intechopen.com/books/recent-advances-in-the-biology-therapy-and-management-of-melanoma/gene-therapy-for-melanoma-progress-and-perspectives

Schematic representation of the wild type counterpart of the typically used recombinant viral vectors. (A) Gammaretroviruses and (B) lentiviruses share similar structures, but differ greatly in their genomes and their impact on cellular function. Gag, pro, pol and env genes encode structural proteins of the capsid, protease, reverse transcriptase and envelope proteins, respectively. The additional lentiviral genes perform regulatory functions as well as alter cellular function. (C) The serotype 5 adenovirus has a protein capsid (non-enveloped) and a large, complex genome that encodes critical genes for viral replication (E1a, E1b) as well as structural and functional genes that regulate both viral and cellular activities.

 Introduction

Gene therapy, the therapeutic transfer of genetic information to a target cell, continues to be a promising alternative in the fight against cancer. In the case of melanoma, the use of an experimental treatment is justified since this disease is incurable in…

View original post 92 more words

Large-ring lactones from plant oils

Green Chemistry International

 

Timo Witta and   Stefan Mecking*a  
Chair of Chemical Materials Science, University of Konstanz, Department of Chemistry, Universitätsstraße 10, 78457 Konstanz, Germany 
E-mail: stefan.mecking@uni-konstanz.de ;
Fax: +49 7531 885152 ;
Tel: +49 7531 882593
 
Green Chem., 2013, Advance Article

DOI: 10.1039/C3GC40905H
Received 15 May 2013, Accepted 11 Jul 2013
First published online 29 Jul 2013
A synthesis route for macrocyclic compounds such as lactones starting from common plant oils has been developed.
Large-ring lactones from plant oils

 
 
Large-ring lactones and lactams were prepared utilising the full fatty acid chain of common plant oils as a source of the macrocycle. Ring closure via acyloin condensation does not require large volumes of solvents for dilution. Nonadecalactone (NDL) and tricosalactone (TCL) can be converted to novel polyesters by ring opening.

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A flexible Pinner preparation of orthoesters: the model case of trimethylorthobenzoate

Green Chemistry International

 

 
Marco Noè,  Alvise Perosa and   Maurizio Selva    

Dipartimento di Scienze Molecolari e Nanosistemi dell’Universita Ca’ Foscari Venezia, Centre for Sustainable Technologies, calle Larga S. Marta, 2137-30123 Venezia, Italy 
E-mail: marco.noe@unive.it

Green Chem., 2013,15, 2252-2260

DOI: 10.1039/C3GC40774H
Received 24 Apr 2013, Accepted 10 Jun 2013

 
The Pinner preparation of orthoesters was revisited achieving remarkable improvements. Outstandingly an unprecedented synthesis of trimethylorthobenzoate starting from benzonitrile has been described.
In the absence of additional solvents,
a novel procedure was implemented for the synthesis oftrimethylorthoesters through the Pinner reaction. At 5 °C, the reaction of both aliphatic and aromatic nitriles (RCN; R = Et, Bu, Ph) with a moderate excess of MeOH and gaseous HCl gave the corresponding imidate hydrochlorides [RC([double bond, length as m-dash]NH)OR′·HCl]
 
in excellent yields (>90%). At 25–65 °C, the methanolysis of alkyl imidate…

View original post 80 more words

Gene Therapy for Melanoma: Progress and Perspectives

New Drug Approvals

media/image1.jpeg

FIGURE 1.

http://www.intechopen.com/books/recent-advances-in-the-biology-therapy-and-management-of-melanoma/gene-therapy-for-melanoma-progress-and-perspectives

Schematic representation of the wild type counterpart of the typically used recombinant viral vectors. (A) Gammaretroviruses and (B) lentiviruses share similar structures, but differ greatly in their genomes and their impact on cellular function. Gag, pro, pol and env genes encode structural proteins of the capsid, protease, reverse transcriptase and envelope proteins, respectively. The additional lentiviral genes perform regulatory functions as well as alter cellular function. (C) The serotype 5 adenovirus has a protein capsid (non-enveloped) and a large, complex genome that encodes critical genes for viral replication (E1a, E1b) as well as structural and functional genes that regulate both viral and cellular activities.

 Introduction

Gene therapy, the therapeutic transfer of genetic information to a target cell, continues to be a promising alternative in the fight against cancer. In the case of melanoma, the use of an experimental treatment is justified since this disease is incurable in…

View original post 92 more words

Analysis Of Vical’s Allovectin-7: Best Results Ever In A Melanoma Phase 3 Trial

New Drug Approvals

check this video

…………….

immunotherapy - cancer

Vical’s (VICL) Allovectin-7 is a pure immune therapy.(1) Which means it does not directly kill cancer cells, but activates the immune system to do so. Vical will soon announce A-7 phase 3 results in Melanoma, but the mechanism of action is not specific to Melanoma, and can be used in any solid tumor cancer.(2) For this reason, I expect that Allovectin-7 will become one of the best selling cancer drugs of all time.

http://seekingalpha.com/article/1584402-analysis-of-vicals-allovectin-7-best-results-ever-in-a-melanoma-phase-3-trial?source=google_news

Allovectin-7 is a substance that is being studied as a gene therapy agent in the treatment of cancer, such as malignant melanoma. It is a plasmid/lipid complex containing the DNA sequences encoding HLA-B7 and ß2 microglobulin – two components of major histocompatibility complex (MHC, class I). It increases the ability of the immune system to recognize cancer cells and kill them.

In 1999, FDA granted Allovectin-7 orphan…

View original post 186 more words

Kiran Mazumdar-Shaw, chairman and managing director of Indian biopharma giant Biocon propels company to clock revenue worth $121 mn

New Drug Approvals

Kiran Mazumdar-Shaw, chairman and managing director, Biocon.

Kiran Mazumdar Shaw: She has the odd passion—artwork, horses—but it’s Biocon that really gives her joy

What do our other billionairesses like to splurge on? Kiran’s abiding passion, apart from her work, are horses and paintings—she particularly enjoys collecting the works of Yusuf Arakkal and S.G. Vasudev. Sailoja confesses she loves Louis Vuitton purses and diamond and gold jewellery. “But I haven’t bought any great jewellery for two years now,” she says. Shobhana admits to a weakness for designer watches and bags, as well as light, trendy and stylish fashion jewellery which is not necessarily very expensive. Ekta loves dressing up—but of course her biggest pleasure comes from watching her audience ratings soar.

For most, making billions is not what drives them. Sulajja, who recently sold a 15 per cent stake in her company to Anil Ambani’s Reliance Capital, could be speaking for…

View original post 1,037 more words